在接受肌肉骨肉瘤治疗的儿童中测量肌肉截面面积的可靠性
Claire Laurie1,2,3, Leo Donnan2,3,4,5, Catherine L Granger1,6
1Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia.
Journal of cachexia, sarcopenia and muscle
|February 12, 2026
概括
肌肉截面面积的磁共振成像 (MRI) 测量对于监测患有骨癌的儿童是可靠的. 最小可检测变化 (MDC) 值有助于识别真正的肌肉损失,以便及时进行干预.
科学领域:
- 儿科瘤学 儿科瘤学
- 肌肉骨成像检查 肌肉骨成像检查
- 瘤学康复康复 瘤学康复
背景情况:
- 肌肉骨健康变化是儿童癌症治疗的显著长期影响.
- 准确的评估方法对于监测与治疗相关的变化至关重要.
- 这项研究的重点是基于MRI的肌肉测量在患有骨癌的儿童的可靠性.
研究的目的:
- 为了确定基于MRI的肌肉截面面积测量的inter-和intra-rater可靠性.
- 用最小可检测变化 (MDC) 值来评估测量精度.
- 评估MRI对监测患有肉瘤的儿童肌肉骨变化的有用性.
主要方法:
- 在第三级儿科癌症中心进行了回顾性队列研究.
- 包括2至17岁的患者接受肌肉骨肉瘤的常规MRI.
- 测量下肢肌肉横截面积由三个训练有素的评分员.
- 通过使用类内相关系数 (ICCs) 评估评价者之间的和评价者内部的可靠性.
- 以最小可检测变化 (MDC) 值评估测量精度.
主要成果:
- 对于psoas,gracilis,中部胃角肌和中部大腿肌/大腿肌周长,评分器间可靠性很好 (ICC > 0.90).
- 对于大腿直肠和大腿两侧肌,具有良好的评分器间可靠性 (ICC > 0.80).
- 在所有被评估的肌肉中,具有优异的 intra-rater可靠性 (ICCs: 0.92-0.99).
- 通过MDC值显示的高测量精度,特别是中肌 (10.62%) 和中肌 (11.69%) 肌肉周长.
结论:
- 肌肉截面面积的MRI测量是患有肌肉骨肉瘤的儿童的可靠工具.
- MDC值可以识别真正的肌肉损失.
- 这种可靠的方法支持癌症治疗期间肌肉骨变化的早期干预.
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