肥胖和肥胖严重程度与9个心血管结果的潜在关联:跨队列协作
Zeina A Dardari1,2, Zhiqi Yao1, Jianjun Zhang2
1Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease, Baltimore, MD (Z.A.D., Z.Y., Y.J., S.B., K.M., M.J.B.).
Circulation
|February 12, 2026
概括
肥胖,尤其是严重的肥胖 (BMI ≥35 kg/m2),显著增加心力衰竭和心房动的风险. 与男性相比,女性在严重肥胖引起的心血管疾病风险的相对增加更大.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肥胖是心血管疾病 (CVD) 的已知危险因素之一.
- 严重肥胖 (BMI ≥35 kg/m2) 与长期心血管疾病结局之间的关系需要进一步澄清.
- 肥胖对心血管疾病影响的性别特异性尚未完全理解.
研究的目的:
- 调查身体质量指数 (BMI) 和一系列长期心血管结果之间的关联.
- 检查与更高的BMI类别相关的心脏病发病风险的性别特异性差异.
- 量化严重肥胖 (2和3类) 严重心血管事件的风险.
主要方法:
- 分析了来自21个队伍的289,875名参与者 (1948-2015).
- 协调的BMI数据和判断的结果包括心肌梗塞,中风,心力衰竭和心房动.
- 多变量Cox比例危险模型,限制立方线,以评估与BMI相关的风险.
主要成果:
- 较高的BMI与大多数心血管结果的风险增加有关,特别是心力衰竭 (HF) 和心房动 (AF).
- 与正常体重相比,2级和3级肥胖症显示HF和AF的风险最高.
- 与男性相比,女性的中风风险,总心血管疾病风险和严重肥胖的全因死亡率相对增加明显.
结论:
- 体重指数升高,特别是严重肥胖,与传统风险因素无关,与HF和AF风险增加密切相关.
- 较高的BMI类别对中风,心血管疾病和全因死亡率的相对风险的显著性别差异表明存在不同的生物机制.
- 对性别特异性生物通路的进一步研究是有必要的,以了解肥胖症中心血管疾病风险差异.
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