协作护理计划对抑郁症结果的影响:现实世界的回顾性分析
Carrie C Wu1,2,3, Adam Ketron1,2,3, William Pirl4
1Department of Supportive Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Palliative & supportive care
|February 12, 2026
概括
这项研究发现,支持性瘤协作实现了与临床试验相比的抑郁反应率. 然而,在现实环境中缺少数据需要改善癌症患者的结果跟踪.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 协作护理模型 (CCM) 在分步护理方法中有效地管理抑郁症.
- 美国临床瘤学会的指导方针建议CCM用于癌症患者的抑郁症.
- 对于癌症中心的CCM,实施和现实世界的数据有限.
研究的目的:
- 在支持性瘤协作计划中评估抑郁症结果.
- 评估NCI指定癌症中心综合行为健康和息护理的可行性和有效性.
- 将现实世界抑郁反应率与随机对照试验 (RCT) 的反应率进行比较.
主要方法:
- 对至少两个患者健康问卷-9 (PHQ-9) 评分的患者进行了回顾性分析.
- 在2022年1月至2023年12月期间收集的数据.
- 抑郁反应被定义为50%的PHQ-9得分降低,在12周和24周评估.
主要成果:
- 平均PHQ-9分数从基线时的17.3下降到12周后的11.1和24周后的10.1.
- 抑郁反应率在12周为34.9%,在24周为54.5%.
- 观察到的响应率与CCMRCT中的响应率相当.
结论:
- 支持性瘤学合作表明,癌症患者的抑郁反应率与RCT相似.
- 缺失数据的高率凸显了现实世界结果跟踪的挑战.
- 需要进一步的评估和策略来改善临床环境中的数据完整性.
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