L-氨酸和Holdemanella biformis之间的相互相互作用调节了刺激性肠道综合征中的肠道屏障功能和焦虑
Chun-Hui Jiang1, Xue Fang1, Wen Huang1
1Department of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.
iMetaOmics
|February 12, 2026
概括
研究人员发现了低水平的l-lysine和肠道细菌增加之间的联系 刺激性肠综合征 (IBS) 中的Holdemanella biformis. 这种相互作用影响肠道屏障功能和焦虑,为IBS和肠-大脑轴障碍提供潜在的治疗点.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 神经胃肠病学 神经胃肠病学
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的疾病,与压力,肠道屏障问题和肠-大脑轴功能障碍有关.
- 宿主代谢物和肠道微生物在IBS中的特定作用尚未完全理解.
研究的目的:
- 为了研究宿主代谢物和肠道微生物在IBS病变的相互作用.
- 确定与海员压力诱导的IBS相关的特定微生物和代谢变化.
主要方法:
- 在航行前和航行后,海员的便样本的综合微生物组和代谢组分析.
- 在干预研究中使用了腹占主导地位的IBS小鼠模型 (l-lysine补充剂和H. biformis管理).
- 进行了体外实验,以检查l-lysine和H. biformis对上皮细胞的影响.
主要成果:
- 在l-lysine和肠道细菌Holdemanella biformis (H. biformis) 之间确定了一种相互相互作用.
- l-lysine被耗尽,而H. biformis的丰富性在旅行诱导的IBS患者中增加.
- 在小鼠中,l-lysine补充改善了肠道屏障完整性,降低了过敏和焦虑,而H. biformis的管理使焦虑恶化.
- 实验室研究表明,l-lysine和H. biformis都促进了上皮的愈合和ZO-1的表达.
结论:
- 在l-lysine和H. biformis之间存在一种对压力敏感的双向代谢循环,影响肠道和神经功能.
- 这个轴对肠道屏障完整性和类似焦虑的行为有互补但相反的影响.
- 针对l-lysine-H. biformis轴为IBS和其他肠-大脑轴障碍提供了潜在的治疗策略.
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