通过神经认知状态将认知变化和阿尔茨海默病生物标志物联系起来
medRxiv : the preprint server for health sciences
|February 12, 2026
概括
在受损成年人中,随着阿尔茨海默病 (AD) 生物标志物增加,个体内认知变异性 (IICV) 增加. 这表明IICV可能是临床环境中跟踪AD进展的敏感措施.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物研究 生物标志物研究
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病.
- 认知变化是神经系统变化的潜在指标.
- 了解影响认知变化的因素对于早期AD检测至关重要.
研究的目的:
- 研究阿尔茨海默病 (AD) 生物标志物与个体内认知变异性 (IICV) 之间的关系.
- 评估IICV是否可以在AD的临床阶段作为敏感的结果指标.
主要方法:
- 利用来自国家阿尔茨海默氏症协调中心的879名成年人 (≥50岁) 的数据.
- 采用温和回归模型来分析AD生物标志物 (CSF Aβ42,p-Tau181,t-Tau;粉胺PET) 和神经认知状态对IICV (iSD,Cov) 的影响.
- 在分析中控制人口因素.
主要成果:
- 在认知障碍患者中,AD生物标志物负担增加与较高的IICV相关.
- 在认知完整的个体中,AD生物标志物和IICV之间没有发现显著的关联.
- 阿尔茨海默病生物标志物和IICV之间的关联强度与它们与平均认知表现的关联相当.
结论:
- 粉样蛋白,蛋白和神经退行性标志物水平升高与认知障碍老年人IICV增加有关.
- IICV显示出作为监测AD进展的敏感结果测量工具的潜力.
- 建议对不同种群进行进一步的纵向研究,以验证这些发现.
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