关键和非关键连接与阿尔茨海默病或血管病理没有不同的关联
medRxiv : the preprint server for health sciences
|February 12, 2026
概括
关键白质连接与非关键连接相比,对SVD或阿尔茨海默氏病 (AD) 病理并不更容易受到伤害. 白质超强度体积同样影响了两种连接类型,AD标志物也显示了类似的效果.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
- 医疗成像医学成像
背景情况:
- 试点研究表明,关键白质 (WM) 连接并不是唯一容易受到SVD或AD的影响.
- 需要进行系统评估,以了解SVD,AD和WM连接漏洞之间的关系.
研究的目的:
- 系统地评估SVD和AD病理和关键与非关键WM连接之间的关联.
- 要确定关键的WM连接是否比非关键的连接更容易受到SVD和AD的影响.
主要方法:
- 扩散张力成像 (DTI) 用于在患有CADASIL,混合病理和自身主导AD (ADAD) 的患者中重建WM网络.
- 在这些网络中定义了关键和非关键连接.
- 线性回归分析评估了SVD标记物 (WMH体积) 和AD标记物 (CSF Aβ42,p-tau,EYO) 与连接强度之间的关联.
主要成果:
- 白物质超强度 (WMH) 量表现出与关键和非关键的WM连接具有同样强烈的关联.
- 阿尔茨海默病标志物 (Aβ-阳性,Aβ42水平,p-tau水平,EYO) 在关键和非关键连接中显示出类似的效果大小.
- 敏感性分析在不同连接定义中证实了这些发现,表明SVD负担对WM完整性的影响超过AD,但对关键连接没有差异性的脆弱性.
结论:
- 无论是SVD还是AD病理,与非关键的相比,关键白质连接的脆弱性都不大.
- 与AD相比,SVD负担似乎对WM整体完整性有更明显的影响.
- 这些发现挑战了关键WM连接对SVD和AD等神经退行性疾病过程具有独特的敏感性的假设.
更多相关视频
相关概念视频
Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Dementia
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
The progression of dementia is generally gradual.
Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...


