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与失眠相关的代谢概况反映了抗氧化剂缺乏,并通过HCHS/SOL中的代谢风险评分与认知衰退相关
medRxiv : the preprint server for health sciences
|February 12, 2026
概括
这项研究确定了与美国西班牙裔/拉丁裔成年人失眠症状相关的特定代谢物. 这些代谢变化也可能导致随着时间的推移,轻度认知障碍 (MCI) 的风险更高.
科学领域:
- 代谢学 代谢学 代谢学
- 睡眠科学 睡眠科学
- 神经科学是一个神经科学.
背景情况:
- 失眠的患病率很高,特别是在西班牙裔人口中,并且与认知能力下降有关.
- 之前关于睡眠障碍的代谢学研究存在局限性,特别是在西班牙裔成年人的失眠方面.
- 这项研究通过调查西班牙裔社区健康研究/拉丁裔研究 (HCHS/SOL) 队列中的代谢物和认知衰退来解决差距.
研究的目的:
- 确定与美国西班牙裔/拉丁裔成年人失眠症状相关的特定血清代谢物.
- 开发和验证对失眠症状的代谢物风险评分 (MRS).
- 探索已识别的代谢物,MRS和包括认知功能在内的交叉表型之间的关系.
主要方法:
- 来自HCHS/SOL研究的6107名参与者的数据分析,分为发现和复制数据集.
- 检查768个血清代谢物和失眠症状,使用LASSO回归来生成代谢物风险评分 (MRS).
- 代谢物协会的复制和MRS与睡眠,认知和心理特征的评估.
主要成果:
- 在发现阶段,有9种代谢物与失眠症状有关,其中2种 (氨酸和氨酸) 被复制.
- 较低的氨酸和氨酸水平与失眠症状的增加相关.
- 经过验证的WHIIRS MRS与七年后患轻度认知障碍 (MCI) 的风险更高有关 (OR: 1.58).
结论:
- 失眠的代谢特征包括饮食和肠道微生物组的代谢物,这表明共享的机制与并发症.
- 与失眠相关的特定代谢物也可能与认知能力下降的风险增加有关.
- 代谢物风险评分显示了预测长期健康风险的潜力,突出了代谢物在睡眠和认知健康研究中的作用.
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