维生素D补充剂对于脂肪性肝病:一个更新的系统审查和随机和非随机干预研究的剂量反应元分析
Ehsaneh Taheri1, Shirin Esmaeili2, Fatemeh Jodeiri3
1Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Current developments in nutrition
|February 12, 2026
概括
对代谢功能障碍相关的脂肪性肝病 (MASLD) 的维生素D补充显示,肝酶和代谢标志物略有改善,但缺乏显著的临床益处. 这种干预是安全的,但对MASLD患者没有提供任何有意义的优势.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种普遍存在的慢性肝病,治疗选择有限.
- 维生素D补充剂由于其提出的安全性和有效性而被探索为MASLD的潜在干预措施.
- 目前的证据需要进行系统的评估,以确定维生素D对MASLD的临床影响.
研究的目的:
- 系统地评估维生素D补充剂对MASLD患者肝脏和代谢参数的影响.
- 为了比较维生素D补充与基线和/或安慰剂反应的结果.
- 为了确定与治疗益处相关的潜在患者子集或干预特征.
主要方法:
- 在多个数据库 (MEDLINE,Scopus,Web of Science,Cochrane Library,clinicaltrials.gov,ICTRP) 进行了系统的搜索相关研究.
- 随机效应元分析被用于汇集28项研究 (21项RCT) 的数据.
- 进行了剂量反应,元回归和子组分析,以探索治疗效应并确定影响因素.
主要成果:
- 维生素D补充剂在FibroScan参数,肝酶 (ALT,GGT),胰岛素耐药性,甘油三和高密度胆固醇的统计学上显著改善.
- 这些改善的程度低于临床上有意义的值,分析显示出不一致性.
- 亚组分析没有确定特定的患者群体或疾病显著受益于维生素D补充剂.
结论:
- 维生素D补充剂在患有MASLD的患者中是安全的,并且耐受良好.
- 尽管某些标志物略有改善,但维生素D补充剂在MASLD中没有为肝脏或代谢参数提供有意义的临床益处.
- 可能需要进一步的研究来澄清维生素D在MASLD管理中的作用,如果有的话.
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