前列腺癌的预后营养指数和存活率:更新的系统综述和元分析
Gang Wang1, Qihang Wu1, Telei Chen1
1Department of Urology, Yinzhou No. 2 Hospital, Ningbo, Zhejiang, China.
Frontiers in nutrition
|February 12, 2026
概括
低预后营养指数 (PNI) 与前列腺癌患者的总生存期 (OS) 和无进展生存期 (PFS) 较短有关. 这一系统性审查为OS提供了中等质量的证据,为PFS提供了低质量的证据,突出了PNI.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 生物统计学 生物统计学
背景情况:
- 预后营养指数 (PNI) 是癌症预后的潜在生物标志物.
- 将PNI与前列腺癌结局联系在一起的证据需要进行系统的评估和质量评估.
- 建议,评估,发展和评估 (GRADE) 的评级框架提供了一种透明的方法来评估证据的确定性.
研究的目的:
- 系统评估前列腺癌患者预后营养指数 (PNI) 的预测值.
- 使用GRADE框架评估关于PNI和前列腺癌预后之间的关联的证据质量.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane数据库进行系统的文献搜索,截至2025年6月.
- 11项研究的元分析 (确定857项),评估PNI与整体生存期 (OS) 和无进展生存期 (PFS) 之间的关联.
- 通过纽卡斯尔-太华尺度评估研究质量;使用GRADE框架对证据确定性进行分级.
主要成果:
- 较低的PNI与较短的OS (HR:2.03;95%CI:1.68-2.46) 和PFS (HR:2.03;95%CI:1.65-2.50) 显著相关.
- 发现了PFS (P=0.014) 的出版偏差,但没有发现OS (P=0.051).
- 敏感性分析证实了结果的稳定性;OS证据被评为中等质量,PFS为低质量.
结论:
- 低PNI是前列腺癌患者较短的OS和PFS的重要预测因素.
- 证据表明PNI与前列腺癌预后之间存在关联,确定性中等至低.
- 需要进一步的前性研究来证实这些发现及其临床影响.
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