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Updated: Feb 13, 2026

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
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Published on: March 30, 2015

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内基因成熟是由通过Na+/H+交换器和pH依赖的Rab GTPase循环进行内外质子信号调节的

Eric Morrow, YouJin Lee, Qing Ouyang

    Research square
    |February 12, 2026
    PubMed
    概括

    通过Na+/H+交换器 (NHE6) 的质子外流激活了Rab7,这是内体成熟中的关键蛋白质. 这一过程在克里斯蒂安森综合征中被破坏,涉及pH敏感相互作用,对神经元健康至关重要,并防止神经退行.

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