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Updated: Feb 13, 2026

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依赖ROC激活LRRK2的结构和生化基础

Quyen Hoang, Yangshin Park, Chunxiang Wu

    Research square
    |February 12, 2026
    PubMed
    概括

    富含白的重复激酶2 (LRRK2) 中的帕金森病突变与其Ras复杂蛋白 (ROC) 域有关. 这项研究揭示了ROC结构交换驱动LRRK2通过分子内途径激活.

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