一个健康的抗菌素耐药性建模:从科学到政策
Carys J Redman-White1,2, Gwen Knight3, Cristina Lanzas4
1Global Agriculture and Food Systems, The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, EH25 9RG, United Kingdom.
抗菌素耐药性 (AMR) 是一个全球性的"健康"问题,需要跨学科的合作. 由于数据差距和异质性,AMR建模是复杂的,但对于有效的政策制定至关重要.
科学领域:
- 一个健康 一个健康
- 流行病学 流行病学
- 环境科学 环境科学
背景情况:
- 抗微生物药物对人类和兽医至关重要.
- 抗菌素耐药性 (AMR) 对全球健康,动物福利和生态系统构成重大威胁.
- 对抗药物耐药性的有效政策指导需要了解其发展,传播和影响.
研究的目的:
- 探索在One Health设置中建模AMR的挑战和机会.
- 确定AMR研究中的关键知识缺口和复杂性.
- 通过对抗药物耐药性建模的务实方法,为政策制定提供信息.
主要方法:
- 召开了一个关于AMR建模的国际研讨会.
- 讨论了数据质量,可用性和知识差距.
- 审查了AMR建模的现状及其证据等级.
主要成果:
- 确定数据质量和可用性的差异是一个主要的挑战.
- 突出了知识差距,特别是抗菌药物使用 (AMU) 和AMR之间的联系.
- 承认AMR在不同环境和生物体中的异质性使得概括性复杂化.
- 强调了制定政策时需要综合性AMR指标的必要性.
结论:
- 建模AMR是必不可少的,但面临重大障碍,包括数据限制和固有的复杂性.
- 跨学科的合作和务实的方法对于制定有效的抗菌药物政策至关重要.
- 从模拟其他环境挑战中获得的经验可以为未来的抗药性政策策略提供信息.
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