临床实践和生物标志物测试对胆道癌症的影响:一项观察性研究
Sabrina Welland1, Ann-Kristin Zöller1, Ilektra A Mavroeidi2
1Dept. of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
胆道癌 (BTC) 的分子检测显示出可变性,但可以识别可操作的基因组变化. 针对这些变化的向治疗改善了BTC患者的整体存活率.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 分子诊断学 分子诊断学
背景情况:
- 胆道癌 (BTC) 具有攻击性,治疗选择有限.
- 对基因组改变 (GA) 的分子测试对于向疗法至关重要,但临床实施不一致.
- 了解BTC中的分子格局和测试实践是必不可少的.
研究的目的:
- 在BTC中评估现实世界的分子测试实践.
- 为了描述BTC的分子格局.
- 评估BTC中选定的GA的预后和预测相关性.
主要方法:
- 来自德国和奥地利18个中心的1521名BTC患者的基因组和临床数据的回顾性分析.
- 对90名患者的两个不同的下一代测序 (NGS) 平台的临床报告进行比较分析.
- 在临床实践中使用的24个不同的NGS面板的评估.
主要成果:
- 在用于治疗决策的NGS小组和报告中观察到显著的变化.
- 较广泛的NGS小组与较窄的小组相比,发现了类似数量的可采取行动的GA.
- 特定的GA如HER2放大,BRAF V600E突变和FGFR2改变显示出潜在的预后意义.
- 接受向治疗的可采取行动的GA患者的整体存活时间明显延长 (31.8个月与22.8个月).
结论:
- 标准化生物标志物测试对于将向疗法整合到BTC管理中至关重要.
- 针对性治疗在BTC中是有价值的,而选择的GA在预测和预后方面都很重要.
- 现实世界的数据凸显了在BTC中协调分子测试策略的需要.
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