肠道微生物群衍生代谢物调节多发性硬化症中CASP3和神经免疫通路:一个整合性的多组学研究
Li Li1, Hongwei Liu2,3, Zhinan Ye4
1Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi Province, China, spph-sx.com.
Mediators of inflammation
|February 12, 2026
概括
肠道微生物及其代谢物通过向Caspase-3来影响多发性硬化症 (MS). 这些代谢物对MS的肠-CNS轴干预具有治疗潜力.
科学领域:
- 神经免疫学 神经免疫学
- 微生物组研究 微生物组研究
- 计算生物学 计算生物学
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性中枢神经系统疾病.
- 多发性硬化症的发病包括神经炎症,免疫失调和肠道微生物群失衡.
- 肠道微生物群的代谢物可以影响MS的发展.
研究的目的:
- 确定与MS相关的基因和微生物代谢物点.
- 研究肠道微生物代谢物在MS中的作用.
- 在肠-中枢神经系统轴中探索潜在的治疗点.
主要方法:
- 综合网络药理学,机器学习和单细胞转录组分析.
- 为了验证,使用了夏普利添加式扩展 (SHAP) 和门德尔随机化 (MR).
- 执行分子对接并评估药物相似性和毒性.
主要成果:
- 确定了卡斯帕酶-3 (CASP3) 作为与微生物代谢产物 (例如,L-单氨酸,D-氨酸) 相互作用的核心标.
- 代谢物可能调节神经免疫通路 (TNF,MAPK,IL-17,加勒).
- 与*Akkermansia*, *Bacteroides*, *Bifidobacterium*等相关的微生物与代谢物;代谢物显示出有利的药物特性.
结论:
- 肠道失调和代谢物显著影响MS的发病和进展.
- 为MS的治疗目标和肠-CNS轴干预提供了基础.
- 需要进一步的实验验证,以确认翻译潜力.
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