相关实验视频
Updated: Feb 13, 2026

10:43
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
4.1K
评估差异化等级作为选择性部剖析早期口腔状细胞癌的决策指南:基于人口的队列研究
Junxu Chen1, Derong Zou1, Hao Zan1
1Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Translational cancer research
|February 12, 2026
概括
瘤分化指导选择性部剖析 (END) 决策在早期口腔平细胞癌 (OSCC) 中. 在中度和差差分化的瘤中,END可以提高存活率,但在差分较好的瘤中却不能.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 癌症研究 癌症研究
背景情况:
- 早期的口腔状细胞癌 (OSCC) 携带隐性淋巴结转移的风险.
- 选择性部剖析 (END) 被用来管理这种风险,但选择标准仍在争论中.
- 瘤分化在指导早期OSCC的END中的作用需要进一步评估.
研究的目的:
- 确定瘤分化是否可以指导早期口腔平细胞癌 (OSCC) 选择性部剖析 (END) 的决策.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库来识别I/II期OSCC患者.
- 根据瘤分化进行了卡普兰-梅尔和考克斯回归分析,以比较END和无END组之间的生存结果 (癌症特异性生存率[CSS]和整体生存率[OS]).
- 进行了分层分析,以评估瘤部位和大小对END的生存益处的影响.
主要成果:
- 在10,396名患者中,END并没有改善差异化瘤的存活率.
- 在中度和差分化/不分化瘤中,END显著改善了CSS和OS.
- 瘤部位和大小改变了END的生存益处,对差异很好,小瘤或口腔底部的瘤观察到的益处有限.
结论:
- 瘤分化是确定END对早期OSCC的生存益处的一个关键因素.
- 对于中度或差差分化/不分化瘤的患者,应考虑使用END.
- 对于具有分化良好的瘤的患者来说,END可能是不必要的.
相关概念视频
Psychosexual Stages of Personality: Oral
3.2K
The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
Weaning, typically occurring...
Weaning, typically occurring...
3.2K
What is Population Genetics?
65.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K
Graded Potential
7.1K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.1K
What are Populations and Communities?
38.0K
Overview
38.0K
Conservation of Small Populations
17.4K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.4K
Population Growth
28.7K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.7K

