针对初级乳腺扩散性大B细胞淋巴瘤的个性化预后:发病率趋势和预测模型
Zhiwei Li1, Zhaojun Wang1, Jieyu Zhou1
1Department of Thyroid Breast Surgery, Dingli Clinical College of Wenzhou Medical University, The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital, Wenzhou, China.
Translational cancer research
|February 12, 2026
概括
主要乳腺扩散性大B细胞淋巴瘤 (PB-DLBCL) 的发病率稳定. 对于超越早期里程碑的患者,生存率有动态的提高,年龄,阶段和化疗是关键的预后因素.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 初级扩散性乳腺大B细胞淋巴瘤 (PB-DLBCL) 是一种罕见的癌症.
- 对于PB-DLBCL预后,人口层面的数据有限.
研究的目的:
- 分析PB-DLBCL发病率的趋势.
- 为了估计动态条件生存 (CS).
- 开发一个总体生存期 (OS) 的预后模型.
主要方法:
- 使用了792名PB-DLBCL患者的监测,流行病学和最终结果 (SEER) 数据 (2000-2021年).
- 计算了年龄调整后的发病率和10年CS概率.
- 开发了一种使用最佳子集回归和考克斯回归的有条件生存名图.
主要成果:
- 在过去二十年中,PB-DLBCL发病率保持稳定 (APC = -0.16%).
- 对于在诊断后的里程碑中幸存下来的患者,条件生存概率显著增加.
- 年龄,安纳伯阶段和化疗被确定为最佳预后因素.
结论:
- PB-DLBCL的发病率稳定,诊断后的生存率有所改善.
- 一种新的有条件生存名图有效地分层风险,并有助于个性化治疗决策.
- 诺米图集成年龄,阶段和化疗,用于动态生存预测.
相关概念视频
Prevalence and Incidence
1.9K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.9K
Diffusion
221.8K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
221.8K
Diffusion
6.6K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.6K
Current Trends in Nursing I
5.5K
Current trends in nursing include:
5.5K
Current Trends in Nursing II
3.6K
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
3.6K
Theories of Dissolution: Diffusion Layer Model
1.8K
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
1.8K


