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Updated: Feb 13, 2026

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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LENG8-AS1:结肠直肠癌中的预后生物标志物 - 差异表达和临床影响
Pardis Jafarnia1, Mohammad Mahdevar2,3, Maryam Peymani1
1Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Indian journal of clinical biochemistry : IJCB
|February 12, 2026
概括
这项研究确定LENG8-AS1是结直肠癌 (CRC) 中的长非编码RNA (lncRNA) 生物标志物. 升调的LENG8-AS1表达与CRC患者的不良预后和瘤进展相关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 大肠直肠癌 (CRC) 是一种普遍存在的恶性瘤,具有不同的基因表达特征.
- 长非编码RNAs (lncRNAs) 在癌症发展中发挥着重要作用.
- 了解lncRNA表达模式对于识别CRC中的新生物标志物和治疗点至关重要.
研究的目的:
- 调查结肠直肠癌 (CRC) 中反意义长非编码RNA (lncRNA) LENG8-AS1 的表达模式.
- 评估LENG8-AS1表达对CRC患者生存结果的影响.
- 探索LENG8-AS1作为CRC.的预后生物标志物的潜力.
主要方法:
- 利用癌症基因组图谱 (TCGA) 数据和TCGA生物链接进行lncRNA候选物鉴定.
- 进行了考克斯回归分析,以将 lncRNA 表达与患者存活率相关联.
- 用Kaplan-Meier图表进行生存预测建模和RT-qPCR用于CRC组织中的表达验证.
主要成果:
- 确定了几个lncRNAs,包括LENG8-AS1,与CRC预后相关.
- 发现LENG8-AS1在CRC组织中被上调并与脂质代谢和血管生成途径中的基因相关.
- 卡普兰-梅尔和ROC曲线分析表明LENG8-AS1作为CRC预后生物标志物的潜力.
结论:
- 在结直肠癌中,LENG8-AS1被上调,并与患者预后不佳有关.
- LENG8-AS1可以作为一个有价值的生物标志物来预测CRC进展和患者生存结果.
- 进一步研究LENG8-AS1在CRC病原发生中的作用是有必要的.
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