全球RNA病毒组潜在辅助代谢基因的功能和进化特征
Yang Zhao1,2,3,4, Zhihao Zhang5,6, Meiling Feng1,2,3,4
1College of Ecology Lanzhou University Lanzhou China.
概括
RNA病毒具有广泛的辅助代谢基因 (AMG),显著扩大它们已知的功能. 这些基因有助于环境适应和遗传处理,影响不同的宿主.
科学领域:
- 病毒学 病毒学
- 转基因组学是指转基因组学.
- 分子生物学分子生物学
背景情况:
- RNA病毒是已知的病原体,但它们的辅助代谢基因 (AMG) 了解甚少.
- 目前对病毒性AMG的知识有限,只有很少的功能类别被确定.
研究的目的:
- 创建RNA病毒辅助代谢基因 (AMG) 的第一个全面目录.
- 扩大已知的病毒AMG的功能多样性.
- 研究编码AMG的RNA病毒的功能作用和宿主范围.
主要方法:
- 病毒基因组的生物信息分析.
- 进行比较的基因组学.
- 病毒基因的功能注释.
主要成果:
- 在25个功能类别中识别了高度多样化的RNA病毒AMG,将已知的类型扩展了75%.
- 大多数确定的AMG都参与环境监管和遗传信息处理.
- 具有AMG的RNA病毒可以感染真核生物和原核生物.
- 有证据表明,AMG可以从病毒预测的宿主范围之外的宿主中获得.
结论:
- RNA病毒编码了广泛的辅助代谢基因,显著增加了它们的功能表.
- 这些AMG增强病毒在环境适应和宿主相互作用中的能力.
- 这些发现揭示了RNA病毒在微生物生态系统和宿主病毒相互作用中的更复杂的作用.
相关概念视频
What is Evolutionary History?
43.7K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
43.7K
Gene Evolution - Fast or Slow?
8.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
8.2K
Global Climate Change
29.0K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
29.0K
Evolutionary Psychology
1.0K
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
1.0K
EDTA: Auxiliary Complexing Reagents
1.4K
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
1.4K
Criticisms of the Evolutionary Perspective
380
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
Evolutionary psychology provides one explanation for these findings, suggesting...
380


