在牛皮患者中阻断IL-17的肠道平衡变化,导致粘膜炎症:一系列病例
Yosuke Shimodaira1, Sho Fukuda1, So Takahashi1
1Department of Gastroenterology and Neurology, Akita University Graduate School of Medicine, Akita, Japan.
Translational gastroenterology and hepatology
|February 12, 2026
概括
在患有牛皮的患者中阻断介质素-17 (IL-17) 信号,增加肠道炎症标志物和改变肠道细菌. 这表明,即使没有临床症状,也可能对肠道平衡产生影响.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 介素-17 (IL-17) 是炎症性疾病中的关键细胞因子.
- 抑制IL-17通路在炎症性肠病 (IBD) 中显示出有限的临床益处,并且可以诱导肠炎.
- 对于IL-17信号阻断对肠道平衡的影响尚不清楚.
研究的目的:
- 为了研究IL-17信号抑制对肠道免疫和恒温的作用.
- 评估抗IL-17治疗后肠道炎症标志物和便微生物群的变化.
主要方法:
- 一个5名耐火性牛皮患者的病例系列,接受了抗IL-17或抗IL-17受体抑制剂的治疗.
- 在治疗前和3个月后评估便免疫化学测试 (FIT),便calprotectin (fCal),内镜检测结果和结肠组织学.
- 使用16S rRNA测序分析便微生物组成.
主要成果:
- 治疗后FIT和fCal水平显著增加,表明肠道炎症加剧.
- 内镜和组织学分析显示粘膜炎症增加和单核细胞透.
- 虽然肠道微生物群的α多样性保持不变,但观察到*蛋白质细菌*的增加.
结论:
- 阻断IL-17信号传递可以诱导肠道的亚临床粘膜炎症.
- 这些发现突显了肠道平衡的改变,尽管没有明显的临床症状.
更多相关视频
相关概念视频
Anatomy of the Intestines
87.9K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.9K
What is Homeostasis?
57.2K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
57.2K
pH Homeostasis
20.0K
Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
Respiratory...
20.0K
Inflammation
62.4K
Overview
62.4K
Skeleton and Calcium Homeostasis
6.1K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.1K
Alterations in Respiration II
1.9K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.9K


