来自肠道的脂多糖的隐藏语言:精细的化学反应,巨大的免疫后果
Marcello Mercogliano1, Valentina Mazziotti1,2, Alba Silipo1,2
1Department of Chemical Sciences and Task Force for Microbiome Studies, University of Naples Federico II Via Cinthia 4 Naples 80126 Italy flaviana.dilorenzo@unina.it.
Chemical science
|February 12, 2026
概括
肠道细菌脂多糖 (LPSs) 并非总是具有炎症性. 它们的化学多样性影响免疫反应,为免疫调节和精确控制宿主微生物相互作用提供了潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 传统上,来自格拉姆阴性细菌的脂多糖 (LPS) 被认为是引发炎症的强效内毒素.
- 胃肠道内有密集的グラム阴性菌群体,使得LPSs丰富,但并不总是与炎症有关.
- 长期暴露于各种LPS可以重新校准先天免疫力,导致耐受性或异常激活.
研究的目的:
- 挑战传统的观点,认为LPSs仅仅是炎症性内毒素.
- 探索由共生源的LPSs的化学多样性及其对免疫反应的影响.
- 了解肠道中LPS介导免疫调节的基础机制.
主要方法:
- 审查了解LPS化学和免疫学的最新进展.
- 分析LPS成分 (脂质A,核心寡糖,O-抗原) 的结构变化.
- 说明LPS结构如何影响受体使用和免疫结果.
主要成果:
- 交叉体LPS表现出显著的化学多样性,微妙的结构变异显著改变了免疫识别.
- LPS结构决定了下游免疫结果,从炎症到耐受性.
- LPS的化学特征可以区分炎症反应,耐受性反应和免疫调节反应.
结论:
- 来自肠道共生动物的LPS具有超出其内毒性活动的复杂免疫调节潜力.
- 了解肠道LPS化学对于重新分类它们在宿主微生物相互作用中的作用至关重要.
- 准LPS结构为开发精准医学新型免疫调节工具提供了蓝图.
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