一个患有三阴性乳腺癌的患者的 pembrolizumab 相关性动脉炎:一个病例报告
Nicolas Ardila1, Camila A Guerrero Bermúdez1, Sergio A Tasco Múnera2
1Internal Medicine, Universidad de Antioquia, Medellín, COL.
Cureus
|February 12, 2026
概括
免疫检查点抑制剂,如pembrolizumab可以引起罕见的动脉炎. 本病例报告详细介绍了一名患有乳腺癌的患者,该患者在接受布罗利祖马布治疗后出现了主动脉炎,并成功使用皮质类固醇治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
- 然而,ICI可以引发与免疫相关的不良事件 (irAEs).
- 血管性IRAE虽然很少见,但可能很严重.
研究的目的:
- 在患有三阴性乳腺癌的患者中报告与 pembrolizumab 相关的稀有风脉炎病例.
- 突出ICI诱导的风炎的诊断和管理挑战.
- 强调识别血管IRAEs的重要性.
主要方法:
- 一个47岁的女性患有三阴性乳腺癌的病例报告.
- 详细的临床表现,诊断工作 (成像,实验室) 和治疗过程.
- 时间关联与 pembrolizumab 管理的审查.
主要成果:
- 患者在 pembrolizumab 输注后的三天内出现了急性主动脉炎.
- 图像检测证实了扩散性大动脉炎症加厚.
- 用高剂量皮质类固醇治疗导致临床和炎症标志物迅速改善.
- 随访成像显示主动脉炎完全消失,癌症没有复发.
结论:
- 布罗利祖马布相关的风脉炎是一种罕见但严重的免疫相关不良事件.
- 及时诊断和皮质类固醇治疗对于有利的结果至关重要.
- 这一案例强调了需要对接受ICI的患者血管并发症保持警的必要性.
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