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Updated: Feb 13, 2026

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Intravitreal Injections in the Ovine Eye
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在静脉内注射法里西马布后,双边出血性闭塞视网膜血管炎和帕努韦炎:一项临床病理学案例研究
Negin Yavari1, Ankur Sudhir Gupta1, Andreas Mitsios2
1Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
American journal of ophthalmology case reports
|February 12, 2026
概括
严重的双边眼内炎症发生在对神经血管与年龄相关的黄斑变性进行内法利西马布注射后. 用皮质类固醇治疗和玻璃切除术解决了出血性闭塞性血管炎和帕努韦炎.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 炎症性眼睛疾病 炎症性眼睛疾病
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 是导致视力丧失的主要原因.
- 静脉内注射是对nAMD的标准治疗方法.
- 法里西马布是一种用于nAMD治疗的新型双特异抗体.
研究的目的:
- 在静脉内注射法里西马布后报告严重双边眼内炎症的病例.
- 描述这种并发症的临床病理特征.
- 概述一个成功的治疗策略.
主要方法:
- 一个80岁的女性患有nAMD的病例报告.
- 记录了视力敏度,眼内压力和前后段的发现.
- 使用光素血管造影,帕斯普拉纳玻璃切除术和玻璃细胞学.
主要成果:
- 患者在faricimab注射后出现了出血性闭塞性血管炎和肺炎.
- 视力敏度显著下降,眼内压力升高.
- 玻璃细胞学揭示了慢性炎症细胞.
结论:
- 内法利西马布可以诱导严重的眼内炎症,包括出血性闭塞性血管炎和帕努韦炎.
- 系统性皮质类固醇,局部疗法和玻璃切除术的及时治疗可以带来有利的结果.
- 玻璃细胞学为这种罕见并发症的炎症机制提供了洞察力.
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