在新生儿期内心血管功能的亚临床变化 婴儿出生于糖尿病母亲的婴儿
Colman I Freel1,2, Ibrahim Alhaji Mohammed2, Alice Lynch2
1Department of Cellular and Integrative Physiology (CIF,* PKM), Division of Newborn Medicine, Department of Pediatrics (CIF,* RAR, ALA-B), College of Allied Health Professions (CKH), University of Nebraska Medical Center, Omaha, NE.
孕产妇糖尿病,特别是1型和2型糖尿病,与新生儿心血管指标 (如血压) 的改变有关. 较高的母体HbA1c与新生儿心血管应变的增加相关,表明早期的生理变化.
科学领域:
- 心脏病学 心脏病学
- 新生儿科学 新生儿科学
- 内分泌学 在内分泌学.
背景情况:
- 母亲糖尿病是已知的先天性心脏缺陷的风险因素.
- 出生时的亚临床心血管功能障碍可以预测后代未来的心血管风险.
研究的目的:
- 调查母亲糖尿病亚型与新生儿心血管指标之间的关联.
- 探索母亲血糖负担和新生儿心血管参数之间的相关性.
主要方法:
- 1927年对心血管指标 (心率,血压) 的分析.
- 对不同母体糖尿病亚型 (GDM,T1DM,T2DM) 和没有糖尿病的心血管指标进行比较.
- 评估母亲的HbA1c,OGTT和新生儿心血管参数之间的相关性.
主要成果:
- 第1型糖尿病与新生儿静脉血压 (SBP),脉压 (PP) 和SBP变异性较高有关.
- 2型糖尿病与新生儿SBP和PP高,SBP变异性较低有关.
- 孕产妇的HbA1c与新生儿的心率,平均动脉压,SBP,透气血压和PP有显著的正相关性.
结论:
- 糖尿病母亲的后代表现出早期的亚临床心血管生理变化.
- 孕产妇糖尿病亚型对新生儿血压有不同的影响.
- 孕产妇的血糖负担与新生儿心血管功能密切相关,这表明时间和严重程度影响结果.
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