在新生儿重症监护病房住院的婴儿中,低剂量和高剂量克隆丁的比较
Jacob Kelner1,2, Clare Riotte2,3, Ursula Marquis4
1Division of Neonatology (JK, SL), Connecticut Children's, Hartford, CT.
概括
从低剂量肠道克罗尼丁 (LDC) 开始似乎与高剂量肠道克罗尼丁 (HDC) 在新生儿重症监护室 (NICU) 治疗疼痛,兴奋和阿片类药物戒断方面同样有效. 这一发现支持LDC作为一个可行的初始治疗策略.
科学领域:
- 新生儿药理学 新生儿药理学
- 儿科重症监护 儿科重症监护 儿科重症监护
背景情况:
- 在高风险的新生儿重症监护室 (NICU) 婴儿中,阿片类药物戒断和激动是常见的.
- 肠道克洛尼丁用于控制这些症状,但最佳剂量策略需要进一步调查.
研究的目的:
- 为了比较低剂量和高剂量的肠道克洛尼丁在治疗NICU婴儿的疼痛,兴奋和阿片类药物戒断的疗效.
主要方法:
- 在IV级NICU接受50周月经后50周前肠内克罗尼丁的95名婴儿的回顾性图表审查.
- 婴儿被分为低剂量 (LDC:<4mcg/kg/day) 和高剂量 (HDC:≥4mcg/kg/day) 的组.
- 结果的比较,包括新生儿疼痛,兴奋和镇静量表 (N-PASS) 评分,超过30天的治疗.
主要成果:
- 在LDC (n=41) 和HDC (n=54) 组之间没有观察到统计学上显著的人口差异.
- 低发达国家和高发达国家群体在30天的治疗期间,N-PASS得分的降低也相似.
- 与HDC组 (8mcg/kg/day) 相比,LDC组获得较低的最大克洛尼丁剂量 (4mcg/kg/day).
结论:
- 以低剂量启动肠道克洛尼丁可能与高剂量一样有效,用于治疗NICU婴儿的疼痛,兴奋和阿片类药物戒断.
- 这项观察性研究表明LDC是一种潜在的有效的替代初始剂量策略.
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