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相关概念视频

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Overview
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Nucleotide Excision Repair01:38

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DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Elements and Compounds01:27

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Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
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Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
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The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
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Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution
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在单核酸分辨率下对ABA响应元素进行高通量定量评估.

Fangnan Sun1, Yaxin Deng1, Weihua Zhao1

  • 1Department of Plant Science School of Agriculture and Biology Shanghai Jiao Tong University Shanghai China.

Quantitative biology (Beijing, China)
|February 12, 2026
PubMed
概括

在酸 (ABA) 响应元素 (ABREs) 中的单核酸变化显著影响基因表达. 核心序列的改变比侧面变化更有影响力,为设计植物促进剂提供了洞察力.

关键词:
在STARR-seqq.酸响应元素的元素这是一个 cis-regulatory 元素.增强剂是一种增强剂.合成促进剂是一种合成促进剂.

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科学领域:

  • 植物分子生物学 植物分子生物学
  • 基因规则 基因规则
  • 植物生物技术 植物生物技术

背景情况:

  • 酸 (ABA) 响应元素 (ABREs) 是控制植物ABA诱导基因表达的关键 cis调节序列.
  • 了解ABRE中的序列变异如何影响它们的功能,对于精确的基因调节至关重要.

研究的目的:

  • 量化评估单核酸替代对ABRE活动的影响.
  • 以单核酸分辨率映射ABRE活动,以指导ABA响应性促进体的设计.

主要方法:

  • 使用合成STARR-seq (自转录激活调节区域测序) 来测量ABRE活动.
  • 评估了核酸替代在ABREs的ACGT核心和ACGT侧翼区域的影响.

主要成果:

  • 在ABRE的核心和侧翼区域的核酸替代明显改变了转录强度.
  • 在ACGT核心序列中的变化对ABRE活动产生了更大的影响,而不是侧边区域的变化.
  • 高度活跃的ACGT侧翼变体显示出特定的下游序列偏好,而高度活跃的核心变体显示出不同的序列模式.

结论:

  • 提供了ABRE活动的定量,单核酸分辨率地图.
  • 这些发现有助于合理设计具有针对农业和研究应用的ABA响应能力的植物促进剂.