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用于人类健康和生物制药工程的基因组规模代谢模型
Feiran Li1, Yu Chen2, Johan Gustafsson3
1Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen China.
Quantitative biology (Beijing, China)
|February 12, 2026
概括
基因组规模代谢模型 (GEMs) 提供了对动物和人类代谢的洞察,有助于疾病研究和生物制药生产. 本综述详细介绍了GEM的发展和用于定量代谢理解的应用.
科学领域:
- 代谢工程是代谢工程.
- 系统生物学 系统生物学
- 计算生物学 计算生物学
背景情况:
- 在过去的15年里,基因组规模代谢模型 (GEMs) 已经为人类和模型动物开发.
- 对于理解新陈代谢,模拟组织相互作用和推进生物制药生产,GEMs至关重要.
研究的目的:
- 审查人类智人和其他动物GEM的历史和发展.
- 为了描述代谢网络的表示,使用静态度矩阵和流量模拟的约束.
- 讨论GEM在理解新陈代谢,疾病和生物制药工程中的应用.
主要方法:
- 代谢网络的表现,使用静态度矩阵.
- 在流量模拟中应用明确的约束.
- 关于GEM在动物中的历史发展和应用的回顾.
主要成果:
- 从智人到其他动物,从通用到特定环境的模拟,GEM的发展已经取得了进展.
- 对动物的GEM的进步显著提高了对人类和相关物种新陈代谢的系统理解.
- GEMs促进模拟多细胞和多组织的代谢相互作用.
结论:
- 动物GEM的进展扩大了我们对新陈代谢的系统理解,有助于人类健康和生物制药工程.
- 未来的研究应该专注于整合更多的生物过程和omics数据,以实现先进的GEM开发.
- 本综述旨在激发哺乳动物生物的新GEM和大数据集成的新算法.
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