在患有慢性乳囊炎的患者中,眼部微生物群类型和纵向微生物群变化,有或没有抗生素预治疗
Shengru Wu1,2, Limin Zhu3, Tingting Wang3,4
1College of Animal Science and Technology Northwest A&F University Yangling China.
概括
慢性乳囊炎 (DC) 的抗生素预治疗可能会破坏眼球微生物群. 这项研究表明,在达克里奥西斯托利诺斯托米之前,它可能不必要,特别是对于非严重的病例,因为康复率相似.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 手术研究的研究.
背景情况:
- 慢性乳囊炎 (DC) 的管理往往包括在乳囊缩术之前进行抗生素预治疗.
- 这种抗生素预处理对眼睛和鼻子微生物群的影响仍然不完全理解.
研究的目的:
- 为了评估抗生素预治疗对接受DC的dacryocystorhinostomy患者的眼睛和鼻子微生物群的纵向影响.
- 为了比较DC患者与没有抗生素预治疗以及与健康对照者之间的微生物群组成和恢复结果.
主要方法:
- 在手术前和手术后1,2,4周,从33名DC患者 (带/不带抗生素预治疗) 沿线采集结膜和鼻子拭子.
- 从46名健康志愿者和14名患有其他眼部疾病的患者中采集结膜袋拭子.
- 对眼睛/鼻子微生物群多样性,丰富性和组成的比较分析,以及临床康复率.
主要成果:
- 与健康对照组相比,没有抗生素预治疗的DC患者在手术前显示出较大的眼球微生物群多样性.
- 虽然临床康复率相似,但抗生素预治疗在手术后4周显著改变了眼球微生物群的丰富性和多样性.
- 在接受抗生素预治疗的患者中,眼部微生物群受到更大的干扰.
结论:
- 在达克里奥西斯托里诺斯托米之前进行抗生素预处理可能会导致眼睛微生物群组成的显著干扰.
- 遗漏抗生素预治疗似乎不会对临床康复结果产生负面影响.
- 对DC患者来说,抗生素预治疗可能不必要,特别是在非严重的病例中,这需要重新评估当前的临床方案.
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