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研究 - - 调查烟草使用与心血管疾病发生率相关的生物标志物
Kennedy Dorsey1, Nubaira Rizvi1, Donald Mercante1
1LSU Health New Orleans School of Public Health.
概括
吸烟显著增加了心血管疾病 (CVD) 的风险,炎症生物标志物可溶性细胞间粘附分子-1和高灵敏性C反应蛋白调解了这种联系. 在这项研究中,电子烟使用与心血管疾病没有显著的关联.
科学领域:
- 心血管健康 心血管健康
- 烟草研究 烟草研究
- 生物标志物发现发现
背景情况:
- 吸烟是心血管健康不良结果的已知危险因素.
- 人口烟草和健康评估 (PATH) 研究提供了数据,以调查烟草使用与心血管疾病 (CVD) 之间的联系.
研究的目的:
- 分析PATH研究数据,以确定特定的生物标志物是否调解香烟或电子烟使用与心血管疾病发生之间的关系.
- 确定与烟草产品消费相关的心血管风险的潜在生物标志物.
主要方法:
- 利用了来自PATH研究 (第1至第5波) 6,473名成年参与者的数据.
- 采用非线性多重添加回归树 (MART) 来对59个生物标志物进行中介分析.
- 参与者分为烟草使用者,电子烟使用者和非使用者,不包括以前患有心血管疾病的参与者.
主要成果:
- 与非吸烟者相比,吸烟者患心血管疾病的几率高出11% (p<0.001).
- 可溶性细胞间粘附分子-1 (sICAM-1) 和高灵敏性C反应蛋白 (hsCRP) 显著调解了吸烟与心血管疾病之间的关联.
- 专用电子烟使用与心血管疾病之间没有发现显著的关联 (p=0.259).
结论:
- 炎症生物标志物sICAM-1和hsCRP是吸烟与心血管疾病之间联系的关键媒介.
- 这些生物标志物可以作为吸烟者的心血管风险指标.
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