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TyG指数和MAFLD严重程度与T2DM患者的亚临床LV功能障碍有关:一个横截面研究
Xiangsui Hu1, Hanwei Chen1, Ziying Wang2
1Department of Ultrasound, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Frontiers in endocrinology
|February 12, 2026
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和高甘油三糖 (TyG) 指数预测2型糖尿病 (T2DM) 中的亚临床左心室功能障碍 (SLVD). 它们的综合评估为早期风险分层提供了一个简单的工具.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 在2型糖尿病 (T2DM) 中很常见,并与心肌问题有关.
- 纤维化-4 (Fib-4) 指数和甘油三糖 (TyG) 指数分别是肝纤维化和胰岛素抵抗的标志物,与心血管疾病 (CVD) 有关.
- 这些标志物对T2DM患者亚临床左心室功能障碍 (SLVD) 的综合影响尚不清楚.
研究的目的:
- 调查T2DM患者肝纤维化,胰岛素抵抗 (IR) 和SLVD之间的关联.
- 探索Fib-4指数和TyG指数对SLVD的独立和互动影响.
- 评估MAFLD在T2DM中SLVD的发展中的作用.
主要方法:
- 招募了270名T2DM患者,通过超声波诊断出MAFLD.
- 使用Fib-4指数评估肝纤维化,使用TyG指数估计IR.
- 通过心声扫描,通过左心室全球纵向菌株 (LV GLS) 确定SLVD,SLVD被定义为▲LV GLS <18%.
主要成果:
- 与非MAFLD患者相比,MAFLD患者的脂质状况较差,TyG值较高,LV GLS较低.
- 无论是MAFLD (OR=3.21) 和TyG指数 (OR=2.73),都独立预测了SLVD.
- 高Fib-4指数 (≥1.3) 和高TyG指数 (≥9.03) 的组合显示出最高的SLVD风险 (OR=7.58).
结论:
- Fib-4指数和TyG指数是T2DM患者SLVD的独立预测指标.
- 肝纤维化和胰岛素抵抗的同时存在对SLVD产生协同作用.
- 对Fib-4和TyG指数的综合评估为T2DM中早期SLVD风险分层提供了有价值的,非侵入性的工具.
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