Baihe Dihuang Tang作为失眠的治疗候选者:针对肠道失调和神经内分泌功能障碍
Liuxi Chu1,2, Qin Lu3,4, Pingping Chen3
1Affiliated Cixi Hospital Wenzhou Medical University Cixi Zhejiang China.
概括
白河迪黄唐 (BDT) 通过改善小鼠行为和恢复神经类固醇和神经递质水平,有效治疗失眠. 它还纠正了肠道微生物群的失调,为治疗失眠提供了一个有希望的自然方法.
科学领域:
- 综合医学是一个整体的医学.
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 传统中医药 (TCM) 配方,如 Baihe Dihuang Tang (BDT) 在历史上一直用于失眠.
- BDT的疗效可能涉及肠道微生物群,神经内分泌系统和血清素通路内的复杂相互作用.
研究的目的:
- 在小鼠模型中研究BDT的抗失眠作用.
- 阐明底层机制,重点关注BDT,肠道微生物群,神经内分泌功能和血清素信号传递之间的相互作用.
主要方法:
- 一个失眠小鼠模型是使用p-甲氨酸 (PCPA) 建立的.
- 小鼠接受了不同剂量的BDT或盐水对照剂的治疗.
- 进行了行为测试 (开放场,升高加迷宫),下丘脑单胺神经递质分析 (ELISA),神经类固醇量化 (HPLC-MS/MS) 和肠道微生物群概况 (16S rRNA 测序).
主要成果:
- PCPA诱导的失眠导致神经类药物,单胺神经递质和肠道微生物群的显著改变.
- 根据剂量,BDT治疗改善了行为参数,包括运动性和睡眠延迟.
- BDT使神经类固醇和单胺水平正常化,表明神经内分泌平衡的恢复.
- BDT调节了肠道微生物群的组成,减少了与失生症相关的特定类和属.
结论:
- 通过改善失眠小鼠的行为缺陷,BDT显示出显著的抗失眠效应.
- BDT通过多种途径起作用,包括恢复神经内分泌和血清系统,并纠正肠道失调.
- BDT是治疗失眠的有希望的候选药物,利用其多方面的作用机制来控制失眠.
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