眼科评估和白病的临床结果:一个7年的回顾性多中心队列研究
Hanne Lamberink1,2, Shantelle A E Ortega1, Isa M Schellekens1
1Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
Open forum infectious diseases
|February 12, 2026
概括
眼球候群病 (OC) 影响近5%的候群病患者,往往没有症状. 在候选血病病例中,迅速进行脑膜扫描可指导抗真菌疗法,并防止视力丧失.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 医学真菌学 医学真菌学
背景情况:
- 眼球候群病 (OC) 是候群病的严重并发症.
- 目前对候选血病患者的脑后镜查的指导方针不一致.
- 这项研究调查了荷兰队列中OC的发生率和影响.
研究的目的:
- 为了确定在接受 fundoscopy 的候选血病患者中 OC 的频率.
- 评估OC对抗真菌治疗选择和持续时间的影响.
- 评估OC患者持续视力丧失的发生率.
主要方法:
- 对有候选血症的成年患者进行了回顾性队列研究.
- 收录标准: *Candida* 种类的阳性血液培养.
- 在76.4%的患者中进行了基底镜检查;OC被定义为胆膜炎或内炎.
主要成果:
- 在接受后视镜检查的患者中,4.9%的患者被诊断出眼球角膜炎.
- 60%的OC患者无症状或无法报告症状.
- 镜检查结果导致所有15名OC患者的抗真菌疗法发生了变化,包括治疗延长和切换.
结论:
- 眼球角膜炎是罕见的,但在candidemia中具有临床意义.
- 镜检测结果对于指导抗真菌治疗决策至关重要.
- 持续的视力丧失是罕见的,发生在20%的OC患者中.
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