介素-2受体和预后营养指数的预测价值在患有扩散大B细胞淋巴瘤的患者中
Fengyang Xie1, Yulan Li2, Xinyu Zhu3
1Department of General Practice, Shanghai Jing'an District Caojiadu Community Health Service Center, Shanghai, China.
Frontiers in medicine
|February 12, 2026
概括
血清互白素-2受体 (IL-2R) 和预后营养指数 (PNI) 可以预测扩散大B细胞淋巴瘤 (DLBCL) 的结果. 高IL-2R和低PNI表明生存率较差,为DLBCL患者提供了更简单的预后工具.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是最常见的侵袭性非霍奇金淋巴瘤 (NHL),其特点是显著的异质性.
- 目前DLBCL的预后标志物,如IPI,基因测序和ctDNA,可能是侵入性的或昂贵的.
- 需要对DLBCL患者分层进行可访问和广泛应用的预后指标.
研究的目的:
- 在DLBCL患者中评估血清中介白素-2受体 (IL-2R) 的预后值.
- 评估DLBCL中预后营养指数 (PNI) 的预后意义.
- 为了确定IL-2R和PNI在不同DLBCL亚型中的适用性.
主要方法:
- 对171名新诊断的DLBCL患者进行了回顾性分析,这些患者接受了标准化疗.
- 相关性分析,最佳切断值的ROC曲线分析,Kaplan-Meier分析和存活率比较的日志等级测试.
- 单变量和多变量考克斯比例危险回归模型,以确定独立的预后因素.
主要成果:
- 血清IL-2R水平与年龄,营养状况和炎症相关;PNI与瘤负担有关.
- 确定了最佳的切割值:IL-2R> 1,202 U/mL和PNI ≤ 44.65.5.
- 高IL-2R和低PNI与晚年,更高的阶段,B症状,更高的IPI得分,更差的性能状态以及显著更短的整体存活期 (OS) 和无进展存活期 (PFS) 相关.
结论:
- 血清IL-2R和PNI是DLBCL的有价值和可访问的预后指标.
- 升高的IL-2R和低的PNI是DLBCL患者预后不佳的独立风险因素.
- 这些标记可以改善预后分层,并指导DLBCL的治疗决策.
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