佩普2TCR:通过转移学习和组合方法准确预测CD4 T细胞受体结合特异性
Kaixuan Diao1,2,3, Tao Wu1, Xiangyu Zhao1
1School of Life Science and Technology ShanghaiTech University Shanghai China.
概括
使用深度学习,Pep2TCR准确地预测了分化4 (CD4) T细胞受体 (TCR) 结合特异性的集群. 这一进步有助于通过克服有限的CD4 TCR数据挑战来开发个性化癌症免疫疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 预测T细胞受体 (TCR) 结合特异性对于理解免疫反应至关重要.
- 对分化的集群4 (CD4) TCRs的有限数据在计算免疫学中构成了重大挑战.
- 现有的模型经常与CD4 TCR相互作用的细微差别作斗争.
研究的目的:
- 开发一个先进的深度学习模型来预测CD4 TCR结合特异性.
- 为解决CD4 TCR研究中的数据稀缺问题.
- 为该领域的研究人员提供一个用户友好的工具.
主要方法:
- 利用深度学习架构来模拟TCR-相互作用.
- 在可用的CD4 TCR特异性数据集上训练模型.
- 开发了一个网络可访问的平台,用于模型部署.
主要成果:
- 与现有方法相比,Pep2TCR在预测准确度方面显著改善.
- 该模型有效地应对CD4 TCR数据有限的挑战.
- 在预测CD4 TCR结合特异性方面取得了高性能.
结论:
- 在预测CD4 TCR特异性方面,Pep2TCR提供了显著的进步.
- 该工具准备加速个性化癌症免疫疗法的研究.
- 通过在线访问,Pep2TCR促进了在免疫学研究中的更广泛应用.
更多相关视频
10:37Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
3.4K
07:00Quantification of Proliferating Human Antigen-specific CD4+ T Cells using Carboxyfluorescein Succinimidyl Ester
Published on: June 4, 2019
9.2K
相关概念视频
Sensitivity, Specificity, and Predicted Value
1.4K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
Sensitivity is the...
1.4K
Internal Receptors
74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Conserved Binding Sites
5.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.2K
The Equilibrium Binding Constant and Binding Strength
15.2K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
15.2K
Receptor-mediated Endocytosis
111.4K
Overview
111.4K
Ligand Binding and Linkage
5.6K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked. In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.6K
