免疫检查点抑制剂相关的胆炎和胰腺炎诱发的penpulimab:一个案例报告
Lumin Xu1, Zhiqiang Bai1, Hang Li1
1Department of General Surgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
AME case reports
|February 12, 2026
概括
本案例研究详细介绍了一名患者,在接受胃癌免疫检查点抑制剂penpulimab治疗后,患上了与免疫相关的胆管炎和胰腺炎. 症状通过干预得到解决,为管理免疫治疗不良事件提供了洞察力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫疗法,特别是免疫检查点抑制剂 (ICI),是晚期癌症的关键治疗方法.
- 普利马布是一种单克隆抗体,向PD-1/PD-L1通路,以抑制免疫抑制.
- 免疫相关的不良事件 (irAEs),如胆管炎和胰腺炎,可能由于免疫系统过度激活而发生.
研究的目的:
- 报告与penpulimab治疗相关的罕见胆道炎和胰腺炎病例.
- 突出这些特定的IRE的诊断和管理方面的考虑.
主要方法:
- 一名患有复发性胃癌的患者接受了penpulimab (200毫克每3周).
- 临床表现,实验室测试 (bilirubin,ALT,AST) 和肝脏活检被用于诊断.
- 治疗涉及药物和手术干预.
主要成果:
- 患者经过12个月的penpulimab治疗后出现黄和肝酶升高.
- 肝脏活检证实了胆道的炎症变化,表明胆道炎.
- 患者还患有胰腺炎,在治疗后,这两种情况都得到改善.
结论:
- 普利马布可能与罕见但严重的不良事件有关,如胆管炎和胰腺炎.
- 这一案例强调了在接受免疫治疗的患者中识别和管理这些irrAEs的重要性.
- 早期诊断和干预对于免疫疗法诱导的器官损伤的良好结果至关重要.
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