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Updated: Feb 13, 2026

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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揭示了婴儿隔离物Bifidobacterium breve的GH42β-银酸酶的转银化开关 DSM20213

Konlarat Phirom-On1,2, Khanh-Trang Vu-Le1,3, Leander Sützl1

  • 1Food Biotechnology Laboratory, Institute of Food Technology, Department of Biotechnology and Food Science, BOKU University, Muthgasse 18, A-1190 Vienna, Austria.

ACS catalysis
|February 12, 2026
PubMed
概括

研究人员通过修改关键酶β-galactosidase (Bbreβgal-III) 来增强银河酸-寡糖 (GOS) 的产生. 突变Arg121显著提高了GOS产量和改变了产品成分,为预微生物合成提供了对酶工程的见解.

关键词:
银-寡糖酸盐 (GOS) 是一种甘氨酸酸酶 (GH) 42家族蛋白质工程工程 蛋白质工程通过galactosylation进行过 Galactosylation的过程.水道的水道这就是β-galactosidase.

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