黑人参提取物对人类胃癌的抗癌作用在异种移植小鼠模型中
Hye Jin Park1, Ha Rin Namkung2, Su Bin Jung2
1Truth and Ginseng Biotechnology Research Co., Ltd. Jinan 55440, Republic of Korea.
American journal of translational research
|February 12, 2026
概括
黑人参提取物 (BGE) 在体外和体内表现出对胃癌细胞和瘤显著的抗癌作用. 这项研究证实了BGE的存在.
科学领域:
- 胃肠道学和瘤学
- 药理学和药物发现
- 自然产品研究自然产品研究
背景情况:
- 胃癌仍然是一个重大的全球健康挑战,需要新的治疗策略.
- 传统的药用植物,如人参,正在越来越多地探索其潜在的抗癌特性.
- 黑人参提取物 (BGE) 是一种经过加工的女性参,含有潜在增强的生物活性化合物.
研究的目的:
- 调查黑人参提取物 (BGE) 在预防和治疗胃癌方面的疗效.
- 在体内评估BGE对人类胃癌细胞增殖和瘤生长的影响.
- 在临床前模型中评估BGE的安全性和无毒性.
主要方法:
- 用人胃癌细胞系 (AGS和KATO III) 进行了细胞毒性和亡测定,这些细胞系接受了BGE治疗.
- 使用AGS细胞建立裸体小鼠异种移植模型,以评估BGE在体内抗瘤作用.
- 在口服BGE或红人参提取物 (RGE) 后,对瘤生长,体重,尺寸和动物体重进行了监测.
- 分析了器官重量 (肝脏,) 和组织病理学,以评估BGE的毒性.
主要成果:
- 在实验室中,BGE对AGS和KATO III胃癌细胞表现出显著的细胞毒性和亡作用.
- 在老鼠异种移植模型中,口服BGE显著降低了瘤重量和大小.
- 与红人参提取物 (RGE) 相比,BGE在减少瘤负担方面表现出更高的疗效.
- 在接受BGE.治疗的小鼠的主要器官 (肝脏,) 中没有观察到显著的毒性.
结论:
- 黑人参提取物 (BGE) 对胃癌具有强大的抗癌活性.
- BGE在抑制胃癌细胞增殖和瘤生长方面是有效的.
- BGE代表了用于胃癌治疗的安全和潜在有效的天然化合物.
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