超声波特征和与乳腺侵入性导管癌瘤瘤大小相关的炎症状况
Xiao-Hong Liu1, Mei-Zhen Fan1, Lin Lin1
1Department of Ultrasound, The Affiliated Hospital of Bei-Hua University Jilin 132000, Jilin, China.
American journal of translational research
|February 12, 2026
概括
侵入性导管癌 (IDC) 中的瘤大小与超声波成像特征相关,并表明炎症水平. 较大的瘤表现出明显的超声波特征和较高的C反应蛋白 (CRP) 和中性粒细胞数量.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 生物标志物 生物标志物
背景情况:
- 侵袭性导管癌 (IDC) 是最常见的乳腺癌类型.
- 了解瘤特征与患者生物标志物之间的关系对于诊断和预后至关重要.
研究的目的:
- 研究IDC患者的超声波特征与瘤大小之间的关联.
- 探索瘤大小,超声检测结果和炎症标志物之间的相关性.
主要方法:
- 对218名女性IDC患者的回顾性分析,按瘤大小分类 (≤2厘米与>2厘米).
- 使用常规超声波 (CUS),对比增强超声波 (CEUS) 和虚拟触摸组织成像量化 (VTIQ).
- 评估炎症标志物,包括中性粒细胞计数和C-反应蛋白 (CRP) 水平;统计分析包括单变量和斯皮尔曼相关性.
主要成果:
- 较大的瘤 (>2厘米) 更多地发生在上外象限,并表现出更丰富的血液流动和更高的CEUS增强.
- 在较大的瘤中,VTIQ显示了明显增加的剪切波速度 (SWV) 参数 (SWV最大,SWV周围瘤平均值,SWVR最大/分钟),与瘤大小相关.
- 在较大的瘤组中观察到CRP水平升高,与瘤大小呈正相关性;中性粒细胞与SWV周围瘤平均值相关.
结论:
- 在IDC中,瘤大小与特定的超声波特征显著相关,包括血管性和组织硬性.
- 超声波成像可以提供关于瘤大小的见解,并可能反映侵入性导管癌的潜在炎症状态.
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