在小细胞肺癌中对PD-L1的免疫组织化学检测及其预后值
1Department of Laboratory Medicine, Affiliated Hospital of Nantong University Nantong 226001, Jiangsu, China.
American journal of translational research
|February 12, 2026
概括
在小细胞肺癌 (SCLC) 中,编程死亡配体1 (PD-L1) 表达与侵袭性疾病有关,并预测生存率差. 免疫组织化学 (IHC) 是一种比RT-qPCR更敏感的方法来评估PD-L1的预后值.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 编程死亡配体1 (PD-L1) 在免疫逃避和癌症进展中发挥作用.
- 与非小细胞肺癌相比,PD-L1在小细胞肺癌 (SCLC) 的预后意义尚未得到充分确立.
研究的目的:
- 为了评估SCLC中的PD-L1表达.
- 为了确定SCLC中PD-L1的预后值.
- 为了比较PD-L1检测方法:免疫组织化学 (IHC) 和逆转录定量聚合酶链反应 (RT-qPCR).
主要方法:
- 用IHC和RT-qPCR测量了66名SCLC患者的结对瘤和非瘤组织中的PD-L1表达.
- 用费舍尔的精确测试分析了临床病理学关联.
- 通过卡普兰-梅尔曲线,日志等级测试和考克斯回归分析来评估生存结果.
主要成果:
- 在34/66名患者中,通过IHC观察到PD-L1阳性.
- 瘤组织的PD-L1mRNA水平明显高于非瘤组织 (P<0.01).
- IHC阳性和高mRNA水平与晚期瘤大小,转移和临床阶段相关 (P<0.05).
- 具有PD-L1阳性的IHC和高mRNA水平与明显更差的5年整体存活率相关 (P<0.05).
- 多变量分析确定了IHC阳性 (HR=2.45,P=0.004) 和高mRNA水平 (HR=2.12,P=0.012) 作为低生存率的独立预测因素.
结论:
- 在SCLC中PD-L1表达与侵略性的临床病理特征有关.
- PD-L1表达独立预测SCLC患者的生存率不佳.
- IHC是一种比RT-qPCR更敏感的方法,用于SCLC中PD-L1的预后评估.
更多相关视频
06:03Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
Published on: January 19, 2019
18.3K
10:29Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Published on: August 14, 2019
11.1K
相关概念视频
Biodiversity and Human Values
17.2K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
17.2K
Professional Values
10.8K
Nurses are responsible for caring for patients during birth, death, illness, and healing. Professional values guide the decisions and actions that nurses make in their careers. If nurses know the decisions and actions to take, providing patients with exceptional care is possible.
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
10.8K
Critical Values
10.4K
A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...
10.4K
z Scores and Unusual Values
11.1K
The z score is one of the three measures of relative standing. It describes the location of a value in a dataset relative to the mean. z scores are obtained after the standardization of the values in a dataset. The z score for the mean is 0.
This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
11.1K
PD Controller: Design
662
In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
662
Absolute and Local Extreme Values
86
The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
86
