使用Life's Essential 8测量的心血管健康与阻塞性睡眠呼吸暂停之间的关联:一个横截面和门德尔随机化研究
Hong Zhai1, Zhouyan Lin1, Minshu Ao1
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University Shanghai, China.
American journal of translational research
|February 12, 2026
概括
保持良好的心血管健康 (CVH) 显著降低了发展阻塞性睡眠呼吸暂停 (OSA) 的风险. 通过生命的基本8 (LE8) 评分来衡量更好的CVH,与减少OSA患病率密切相关.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- 通过生命的基本8 (LE8) 构造来评估心血管健康 (CVH),影响了许多健康结果.
- 阻塞性睡眠呼吸暂停 (OSA) 是一个日益严重的公共卫生问题,已知与CVH有联系,但这种关系需要进行更深入的调查.
研究的目的:
- 调查通过LE8得分量化的CVH与OSA患病率之间的关联.
- 使用孟德尔随机化探索CVH和OSA之间的因果关系.
主要方法:
- 利用来自国家健康和营养检查调查 (NHANES) (2005-2008,2015-2018) 的9,350名成年人 (20-79岁) 的数据.
- 使用后勤回归来分析LE8分数与OSA之间的关联.
- 应用了两个样本的门德尔随机化与反变量权重 (IVW) 方法来评估因果关系.
主要成果:
- 具有较好的CVH (较高的LE8得分) 个体表现出明显较低的OSA几率 (OR:0.23,95%CI:0.18-0.30).
- 观察到一种剂量依赖的关系,其中较高的LE8得分与OSA风险降低相关.
- 基因决定的更高的BMI,吸烟和较低的体力活动与增加的OSA风险有关.
结论:
- 保持最佳的心血管健康,如LE8得分所示,对于降低阻塞性睡眠呼吸暂停的风险至关重要.
- 这些发现强调了促进CVH的公共卫生倡议的重要性,以减轻OSA患病率.
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