在接受脊柱手术的高血压患者中,雷米马佐拉姆和普罗波之间的低血压发病率比较
Jing Cui1, Xinyu Qi1, Junjie Wang1
1Department of Anesthesiology, Peking University International Hospital Beijing 102206, China.
American journal of translational research
|February 12, 2026
概括
在接受脊柱手术的高血压患者中,雷米马佐拉姆的低血压发病率较低,PONV和注射疼痛等不良事件也较少,与普罗波相比. 这表明雷米马佐拉姆可能是这个患者群体更安全的麻醉选择.
科学领域:
- 麻醉学 麻醉学
- 心血管麻醉心血管麻醉
- 神经外科 神经外科
背景情况:
- 接受脊柱手术的高血压患者有增加的手术内低血压的风险.
- 普罗波是一种常见的麻醉剂,但其使用可能与血液动力学不稳定性有关.
- 雷米马佐拉姆是一种较新的超短效二甲,在血液动力学管理中具有潜在的优势.
研究的目的:
- 为了比较经过脊柱手术的高血压患者中雷米扎洛兰和普罗波之间的手术内低血压的发生率.
- 评估与每个麻醉剂相关的术后不良事件.
主要方法:
- 对194名接受脊柱手术的高血压患者进行了回顾性分析.
- 患者接受了雷米马佐拉姆 (n=99) 或普罗波 (n=95) 作为主要麻醉剂.
- 术内低血压定义为平均动脉压 (MAP) <80%的基线;严重的低血压作为MAP <70%的基线.
主要成果:
- 在雷米马佐拉姆组 (82.83%) 与普罗波组 (93.68%) (P=0.019) 中,低血压的发病率较低.
- 雷米马佐拉姆组的术后恶心和吐 (PONV) 率显著降低 (15.15%对比29.47%,P=0.016) 和注射疼痛 (2.02%对比26.32%,P<0.001).
- 雷米马兰是一种独立的抗低血压保护因子 (OR=0.435,95% CI:0.210-0.901,P=0.025).
结论:
- 在接受脊柱手术的高血压患者中,雷米马佐拉姆与手术内低血压的风险显著降低,与普罗波相比.
- 雷米马佐拉姆的使用导致术后不良事件减少,包括PONV和注射疼痛.
- 雷米马佐拉姆可能是接受脊柱手术的高血压患者更安全的麻醉选择.
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