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Updated: Feb 13, 2026

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非小细胞肺癌患者免疫力和生存率的差异:肠道微生物群的前景
Hao Liao1, Xiangping Luo1, Liqin Jiang2
1Department of Orthopedics, The Affiliated Hengyang Hospital of Hunan Normal University (Hengyang Central Hospital) Hengyang 421001, Hunan, China.
American journal of translational research
|February 12, 2026
概括
像Bifidobacterium和Lactobacillus这样的有益肠道细菌与非小细胞肺癌 (NSCLC) 患者的更好的免疫反应有关,这些患者接受了免疫检查点抑制剂治疗. 相反,肠杆菌和大肠杆菌与较差的结果相关.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物组的组成越来越被认为是癌症治疗疗效的调节器.
- 了解肠道细菌和宿主免疫之间的相互作用对于改善非小细胞肺癌 (NSCLC) 的结果至关重要.
研究的目的:
- 研究特定肠道细菌 (肠杆菌,大肠杆菌,双菌,乳酸菌) 与中国NSCLC患者的免疫功能之间的关联.
- 探索肠道微生物群,免疫状态和预后之间的关系,包括对免疫检查点抑制剂 (ICI) 的反应.
主要方法:
- 对208名NSCLC患者关键细菌种群的便样本进行定量分析.
- 在周围血液中通过流细胞计测量T淋巴细胞子集 (CD3+,CD4+,CD8+) 的测量.
- 微生物丰富度,免疫变量和6个月ICI疗效和生存结果之间的相关性分析.
主要成果:
- ICI反应者显示Bifidobacterium和Lactobacillus水平较高,而非反应者则增加了Enterococcus和E. coli.
- 双杆菌和乳杆菌与T细胞计数正相关,与炎症性细胞因子 (IL-6,TNF-α) 负相关.
- 肠杆菌和大肠杆菌与T细胞呈现负相关性,与炎症性细胞因子呈现正相关性.
结论:
- 双杆菌和乳杆菌促进抗炎作用和T细胞激活,支持NSCLC的抗瘤免疫力.
- 这些发现突显了调节肠道微生物群的潜力,以增强NSCLC患者的免疫反应和治疗疗效.
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