在接受人工关节和膝关节置换的患者中,术前营养状况和术后临床结果之间的相关性
Yongjie Cai1, Hong Zhang1, Jianling Yang1
1Department of Orthopedics, The Third Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital Chengdu 611730, Sichuan, China.
American journal of translational research
|February 12, 2026
概括
预后营养指数 (PNI) 低可能会增加关节整形术后的不良结果. 结合PNI,T2DM,疾病持续时间和WOMAC评分的新型诺摩格拉姆模型有助于评估术后风险.
科学领域:
- 整形外科手术 整形外科手术
- 临床营养学 临床营养学
- 预测建模预测建模
背景情况:
- 整体关节整形术 (THA/TKA) 的结果受到各种因素的影响.
- 预后营养指数 (PNI) 是一种营养状况指标.
- 确定THA/TKA中不良结果的预测因素对于患者管理至关重要.
研究的目的:
- 评估手术前预后营养指数 (PNI) 对接受全关节整形手术 (THA/TKA) 的患者临床结果的影响.
- 开发和验证THA/TKA患者不良临床结果的诺莫格拉姆预测模型.
主要方法:
- 对504名THA/TKA患者的回顾性分析.
- 后勤回归分析以确定独立的风险因素.
- 使用PNI,T2DM,疾病持续时间和WOMAC分数构建和验证名录预测模型.
主要成果:
- 71名患者 (14.09%) 经历了不良结果.
- 2型糖尿病 (T2DM) 和疾病持续时间≥10年是不良结果的独立风险因素.
- 较高的WOMAC分数与不良结果的增加相关,而较高的PNI水平与风险的降低相关.
- 在内部和外部验证中,名图表显示出良好的区分和校准.
结论:
- 低的手术前PNI与THA/TKA患者出现不良结果的风险增加有关.
- 开发的诺米图,包括PNI,T2DM,疾病持续时间和WOMAC评分,是临床风险评估的宝贵工具.
- 该模型可以帮助临床医生预测和管理THA/TKA患者的术后风险.
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