相关实验视频

Updated: Feb 13, 2026

Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells
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Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells

Published on: April 2, 2016

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在使用RNP介导的CRISPR-Cas9基因删除的初级小鼠原生和记忆T细胞中查询功能驱动因素

Surojit Sarkar, Yevgeniy Yuzefpolskiy, Vandana Kalia

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    概括

    这项研究引入了CRISPR-Cas9方法,用于在CD8 T细胞中快速删除基因,绕过了淘汰小鼠的需求. 这加速了针对感染和癌症的免疫反应的研究.

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    CRISPR/Cas9 Ribonucleoprotein-mediated Precise Gene Editing by Tube Electroporation

    Published on: June 20, 2019

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    Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas908:27

    Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

    Published on: April 10, 2018

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    Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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