通过使用休息状态fMRI在阿尔茨海默氏症病谱中调查白质功能网络连接.
bioRxiv : the preprint server for biology
|February 12, 2026
概括
阿尔茨海默病 (AD) 显示了白质 (WM) 功能连接的改变,即使在轻度认知障碍 (MCI) 中也是如此. 这项研究揭示了WM功能网络连接在AD频谱中的变化,这表明它是潜在的生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 生物标志物发现发现
背景情况:
- 白物质 (WM) 在历史上被视为功能惰性在fMRI研究.
- 新出现的证据强调了WM在BOLD波动和功能连接中的作用.
- 了解WM的功能变化对于神经退行性疾病研究至关重要.
研究的目的:
- 在阿尔茨海默病 (AD) 谱中调查WM功能网络连接 (FNC) 的变化.
- 在认知正常 (CN),轻度认知障碍 (MCI) 和AD组中评估WMWM,灰质 (GM) GM和WMGM连接性改变.
- 探索WM sFNC作为潜在的AD分期和监测的生物标志物.
主要方法:
- 利用了来自阿尔茨海默病神经成像计划 (ADNI) 队列 (CN,MCI,AD) 的静止状态fMRI数据.
- 应用导向独立组件分析 (ICA) 使用202个内在连接网络 (ICN) 的多尺度模板.
- 计算了静态功能网络连接 (sFNC) 并进行了群组比较,并进行了统计纠正.
主要成果:
- 在AD中观察到WMWM和WMGM连接的显著变化,涉及额头,感觉运动和皮时网络.
- 即使在MCI患者中,与CN患者相比,WMGM连接中断也很明显.
- 具体的干扰包括减少的GMcerebellar:WMfrontal合和增加的GMhippocampal到WMfrontal连接.
结论:
- 在AD连续体中,WM功能连接是可测量的,并且可以选择性地改变.
- 在明显的痴呆发作之前,WM电路的功能障碍就会出现.
- WM sFNC为AD管理提供了基于GM的措施的补充生物标志物.
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