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Updated: Feb 13, 2026

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
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A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

Published on: July 15, 2021

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遗传性肺动脉高血压的大型动物模型使用基因编辑的BMPR2羊

Sanjeev A Datar, Nicholas Werry, Austin R Brown

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    概括

    研究人员开发了一种针对遗传性肺动脉高血压 (PAH) 的新型羊模型. 该模型模仿了由BMPR2基因突变引起的人类PAH,有助于未来的研究和治疗评估.

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