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Updated: Feb 13, 2026

Primer-Free Aptamer Selection Using A Random DNA Library
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与生物类分子相似度越来越大的和越来越小的对接库的选择性影响

Brendan W Hall, Kensuke Sakamoto, Xi-Ping Huang

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    概括

    超大型的虚拟图书馆产生了具有高命中率的新药候选者. 然而,这些化学上多样化的分子表现出与生物类化合物类似的非向效应,这表明选择性独立于图书馆相似性.

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