-tACS调节了依赖于奖励的学生反应和皮层状连接
bioRxiv : the preprint server for biology
|February 12, 2026
概括
腹侧前额皮层 (VLPFC) 的非侵入性大脑刺激通过调节兴奋和皮质前额皮层网络来影响奖励处理. 这种方法提供了一种新的方法来研究和潜在地治疗奖励功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 心理学 心理学 心理学
背景情况:
- 非侵入性脑刺激有助于理解奖励处理的神经机制.
- 像TMS和tES这样的当前方法难以到达深层大脑区域,例如条纹体.
- 腹侧前额皮层 (VLPFC) 与条纹体有很强的连接,这表明潜在的间接调制.
研究的目的:
- 调查刺激VLPFC是否可以间接影响与奖励处理相关的神经和生理反应.
- 检查跨交替电流刺激 (α-tACS) 对奖励相关活动和连接性的影响.
主要方法:
- 参与者接受了一项猜牌任务,并获得金钱奖励/惩罚.
- 在α-tACS针对VLPFC或对照区域时,同时使用功能磁共振成像 (fMRI) 和瞳孔测量.
- 测量包括瞳孔扩张,大脑激活 (BOLD) 和腹条纹 - 背前环状皮层 (VS-dACC) 功能连接.
主要成果:
- 在奖励和惩罚期间,VLPFC刺激增加了瞳孔扩张,这表明生理兴奋升高.
- α-tACS调节了VLPFC活动,在奖励期间增强了它,在惩罚期间抑制了它.
- 刺激改变了VS-dACC连接的情境依赖,与瞳孔扩张相关的变化.
结论:
- 用α-tACS针对VLPFC,在奖励处理过程中有效调节局部皮质活动和皮质前皮质网络.
- 这提供了一种有希望的非侵入性方法来影响奖励回路.
- 研究结果将大脑活动,连接性和奖励处理中的自主反应联系起来.
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