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相关概念视频

RNA Editing02:23

RNA Editing

9.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.9K
RNA Structure01:23

RNA Structure

79.2K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.2K
RNA Structure01:19

RNA Structure

7.7K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
7.7K
Self-Awareness and Its Effects01:21

Self-Awareness and Its Effects

318
Self-awareness is a psychological state in which the individual becomes the focal point of their attention. This inward focus transforms the self into an object of contemplation and assessment, influencing how individuals perceive their actions and their alignment with personal and societal standards.Triggers and Contexts for Self-AwarenessSelf-awareness can be activated by external stimuli that make individuals visually or audibly aware of themselves, such as mirrors, cameras, or recordings.
318
Altered States of Awareness01:06

Altered States of Awareness

1.2K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.2K
Subconsciousness and No Awareness01:15

Subconsciousness and No Awareness

721
The concept of subconscious awareness refers to the processing of information below the level of conscious thought, which significantly influences both behaviors and decisions. It is also known as waking subconscious awareness. This complex level of cognition operates without the direct awareness of the individual, facilitating rapid and simultaneous handling of multiple information streams.
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
721

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相关实验视频

Updated: Feb 13, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
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RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

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结构感知图形学习预测RNA可编辑性跨组织和物种.

Zohar Rosenwasser, Michael Levitt, Erez Y Levanon

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    概括

    预测ADAR酶对RNA的编辑是具有挑战性的. 一个新的图表注意力框架,A dar E dit,通过考虑RNA结构,准确地预测RNA编辑站点,优于基于序列的模型.

    科学领域:

    • 生物化学 生物化学
    • 计算生物学 计算生物学
    • 基因组学就是基因组学.

    背景情况:

    • 由ADAR酶介导的腺酸-伊诺酸 (A-to-I) RNA编辑是具有治疗潜力的关键转录后修饰.
    • 预测A-to-I编辑站点是很困难的,因为它依赖于双链RNA (dsRNA) 几何和稳定性,而不仅仅是序列.
    • 目前的模型很难捕捉ADAR酶识别的复杂结构决定因素.

    研究的目的:

    • 开发一个结构明确的计算框架,用于预测A-to-IRNA编辑站点.
    • 通过结合dSRNA结构特征来提高预测RNA编辑的准确性.
    • 在不同物种中研究ADAR基质识别的保存原则.

    主要方法:

    • 开发了A dar E dit,一个图表注意力框架,将dsRNA基质表示为带有脊柱和基对边缘的核酸图.
    • 通过类型交互和动机敏感序列分支来增强图形表示.
    • 训练并评估了在人类反转的Alu双重体上的模型,使用RNA折叠预测的二次结构和GTExRNA-seq数据.

    主要成果:

    • 在多种组织环境中,A dar E dit的表现始终优于单序CNN,变压器和RNA语言模型.
    • 在组合的人体组织数据上取得了高的歧视性能 (AUROC/AUPRC = 0.96; F1 ≈ 0.90).

    更多相关视频

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    RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

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    相关实验视频

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    RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

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  • 证明了图表表现的成功转移到进化上遥远的非阿鲁物种,揭示了保存的ADAR识别原则.

    • 结论:

    • 一个dar E dit提供了一个强大的,结构意识的方法来预测A-to-IRNA编辑站点.
    • 这些发现突显了dsRNA结构在ADAR基质识别中的重要性,在物种之间保留了原则.
    • 该模型的注意力概况和突变发生分析提供了对生物化学约束和对RNA编辑的远程结构影响的见解.