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Updated: Feb 13, 2026

Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System
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Published on: July 30, 2018

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索塔雷cept通过重新编程BMPR2/TGF-β-HIF-1α信号通路来逆转SIN3a缺陷驱动的PAH

Katherine Jankowski, Anurupa Ghosh, Maria T Ochoa

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    概括

    切换器独立的3a (SIN3a) 损失通过破坏BMPR2信号来加速肺动脉高血压 (PAH). 索塔cept治疗逆转PAH,恢复SIN3a和BMPR2表达,突出SIN3a作为治疗点.

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