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Updated: Feb 13, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Published on: January 31, 2025

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三胞胎症21改变了Sonic Hedgehog信号蛋白的状局部

Wolfgang E Schleicher, Bailey L McCurdy, Cayla E Jewett

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    概括

    唐氏综合征 (三位一体 21) 通过减少初级眼中的滑化 (SMO) 蛋白质,损害了Sonic Hedgehog (SHH) 信号传输. 迟缓的乳毛成熟可能解释了这种缺陷,影响了SHH通路的功能.

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